ELSEVIER Biochemical engineering Journal 2 ( 1998) Biochemical Engineering Journal 1 l-21 A structured seat for penicillin proceeds on mixed substrates G.C. Paul, M.T. Syddall, C.A. Kent, C.R. Thomas * Centre for Bioprocess Engineering, domesticate of chemical Received Engineering, 23 January The University of Birmingham, 1998; accepted 7 May Edgbaston, Birmingham, B15 2lT, UK 1998 go up A structured energising modelpreviouslydeveloped describe growth,differentiation, penicillinproduction Penicillium chryysoto the and of genum has been compound andextended orderto apply it to a mixedcarbonsource fermentation. filamentous in The hyphae dividedinto are quad distinctregions thebasis theiractivitiesandthephysiological on of structure (i.e., vacuolation)of thehyphalcompartments: actively viz., growing(mainly apical)regions, non-growing penicillinproducing or regions, vacuoles, degenerated metabolica lly and or inactiveregions. A simpleapproach takento give quantitative is descriptions hyphal extension, of branchformation,vacuolation differentiation.The and fermentation medium contained lucose andlactose g monohydrate the maincarbonsources.
The source the lactose whey powder as of was give in excess in theinoculum medium, whilstglucose fedcontinuously was throughout fermentation. the Lactose,disaccharide, is hydrolysed a to cardinal monosaccharides, glucose and gaiactose, when the rest period glucose concentration in the medium drops to a very gloomy level. The utilisationof glucos e that of galactose and following the hydr! olysisof lactosewereobserved occursimultaneously. allowedthe to This assumption simplelactoseutilisationkineticsin which lactosehydrolysiscould be considered producingan equivalentamountof of as glucose. model been sed for successful The has u predictions fed-batch of penicillinfermentations usinganindustrial chyogenum strain P. under...If you take to tick a full essay, order it on our website:
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